I find the reddish blemish just above the bridge of Grandma's nose a bit distracting. We can erase it by dabbing it a bit with some of her natural skin color.
Click on the Clone Stamp tool (in the fifteenth spot from the top of the toolbar) and change the size of the tool to about 12 pixels using the options toolbar at the top of the screen. While you're there, set the opacity of the Clone Stamp to about 50 percent. Then, Alt-click on some part of her face that has an even, natural look. You've just assigned that as the source of the clone effect. Now click the brush on the blemish above Grandma's nose. Just dab at it, clicking around to eliminate the reddish tone. Dabbing with the Clone Stamp set to a low opacity does more than just erase blemishes; both faces in this picture have some unsightly reflections from the flash, so work them slightly with the brush as well.
As you dab different parts of the face, take new source-location samples near the area you're working with. In this picture, the most important spots to get are the tips of both noses--it's like applying a bit of makeup to an actor's nose to absorb reflections from the studio lights.
The Clone Stamp can even help eliminate the reflection in the eyeglasses. First sample a region that has the same skin tone as around the eyes. Then zoom in far enough that you can easily see the problem area. Reduce the size of the stamp (I set it around 8 pixels), and dab gently to take the edge off the reflection. Don't go overboard here, though, because there are important details that you don't want to remove.